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    黃逸生

    黃逸生

    醫(yī)生職稱:腫瘤專家 主任醫(yī)師 博士 教授 碩士研究生導(dǎo)師

    所屬科室:腫瘤科

    擅長(zhǎng)項(xiàng)目:專長(zhǎng)于肺癌、乳腺癌、腸癌、胃癌、肝癌、鼻咽癌、食管癌、宮頸癌診治

    專家介紹:

    社會(huì)地位:

    國(guó)家腫瘤微創(chuàng)聯(lián)盟肺癌專業(yè)委員會(huì)委員

    廣東省藥理學(xué)會(huì)乳腺科用藥委員會(huì)常務(wù)委員

    廣東省保健協(xié)會(huì)乳腺保健分會(huì)常務(wù)委員

    廣東省藥理學(xué)會(huì)治療藥物監(jiān)測(cè)研究專業(yè)委員會(huì)委員

    廣東省中西醫(yī)結(jié)合學(xué)會(huì)腫瘤姑息治療專業(yè)委員會(huì)委員

    廣東省精準(zhǔn)醫(yī)學(xué)應(yīng)用學(xué)會(huì)乳腺腫瘤分會(huì)委員

    黃逸生,現(xiàn)任廣州現(xiàn)代腫瘤醫(yī)院特聘腫瘤專家,原廣東省人民醫(yī)院主任醫(yī)師,主任醫(yī)師,碩士研究生導(dǎo)師,廣州中醫(yī)藥大學(xué)教授。發(fā)表學(xué)術(shù)論文30余篇,其中SCI收錄論文18篇。負(fù)責(zé)或參與國(guó)家、省市課題9項(xiàng)。

    2006年10月,以第一作者撰寫(xiě)論文《新輔助化療對(duì)非小細(xì)胞肺癌預(yù)后影響Meta分析》,在2005年至2006年腫瘤類論文評(píng)選中榮獲由中國(guó)抗癌協(xié)會(huì)頒發(fā)的優(yōu)秀論文獎(jiǎng)。

    2009年12月論文《吸煙狀況對(duì)厄洛替尼治療晚期非小細(xì)胞肺癌療效影響》獲由中國(guó)肺癌雜志主辦的“厄洛替尼-見(jiàn)證中國(guó)NSCLC治療新突破”全國(guó)征文比賽二等獎(jiǎng)。

    2010年8月論文《Impact of smoking status and pathological type on EGFR mutations in lung cancer》獲由中華醫(yī)學(xué)會(huì)《中華醫(yī)學(xué)雜志英文版》編輯部主辦的全國(guó)腫瘤專業(yè)有獎(jiǎng)?wù)魑谋荣惗泉?jiǎng)。

    項(xiàng)目《肺癌個(gè)體化靶向治療模式的建立與推廣》于2013年2月獲廣東省科學(xué)技術(shù)一等獎(jiǎng),粵府證[2013]2018號(hào),項(xiàng)目編號(hào):B14-0-1-03-R14。作為研究者參與多項(xiàng)國(guó)際多中心臨床試驗(yàn),是TRUST試驗(yàn)、CTONG0803、CTONG1201 試驗(yàn)全國(guó)協(xié)調(diào)研究者。

    主持或參加科研項(xiàng)目及人才計(jì)劃項(xiàng)目情況(按時(shí)間倒排序):

    1、中山市社會(huì)公益科技研究項(xiàng)目(醫(yī)療衛(wèi)生)重大項(xiàng)目,2016B1012,細(xì)胞因子IL-11在肺腺癌腦轉(zhuǎn)移EGFR-TKI治療后耐藥中影響,2017.1-2019.12,25萬(wàn),在研,主持。

    2、廣州市科技計(jì)劃,201510010214,細(xì)胞因子IL-11在逆轉(zhuǎn)EGFR-TKI耐藥肺腺癌腦轉(zhuǎn)移中作用,2015.6-2018.6,20萬(wàn),在研,主持。

    3、國(guó)家自然基金,81502439,肺癌高發(fā)家系橫向研究的基因組DNA突變及RNA轉(zhuǎn)錄的傳遞與調(diào)制,2016.1-2018.12,18萬(wàn),在研,主要參與(第三)

    4、廣東省醫(yī)學(xué)科學(xué)技術(shù)研究基金,A2014034,非吸煙肺癌EGFR突變、肺癌家族聚集和GST多態(tài)性的關(guān)聯(lián)性研究,2014.10-2016.10,0.5萬(wàn),在研,主持。

    5、廣東省科技計(jì)劃,2012B031800163,肺癌靶向藥物厄洛替尼個(gè)體化治療優(yōu)化,2013.01-2015.12,2萬(wàn)元,在研,主持。

    6、廣州市科技計(jì)劃,2010YI-C931,細(xì)胞色素P4503A4基因多態(tài)性對(duì)厄洛替尼毒性影響,2011.01-2014.12,6萬(wàn)元,結(jié)題,主持。

    7、廣東省科技計(jì)劃,2010B031500031,細(xì)胞色素P450 3A4基因多態(tài)性與厄洛替尼毒性相關(guān)性研究,2011.01-2014.12,3萬(wàn)元,結(jié)題,主持。

    8、吳階平臨床科研基金,320.6700.09043,細(xì)胞色素P4503A4、2D6基因多態(tài)性對(duì)吉非替尼毒性影響,2010.01-2014.12,10萬(wàn)元,準(zhǔn)備結(jié)題,主持。

    9、廣東省醫(yī)學(xué)科研基金,A2009036,索拉非尼聯(lián)合順鉑對(duì)胃癌的協(xié)同作用及機(jī)制, 2009.06-2012.06,0.5萬(wàn)元,已結(jié)題,參與。

    發(fā)表論文:       

    1. Huang H , Huang Y . Association between beverage consumption and liver fibrosis. Journal of hepatology 2018 Jan 6;(通訊作者)

    2. Xu XF , Yu JJ , Huang YS , Han J , Li ZL , Zhang H , Yang T . Surgical site infections following pancreaticoduodenectomy. HPB : the official journal of the International Hepato Pancreato Biliary Association 2017 Dec; 19 (12 ):1130. (共同第一)

    3. Wang Z , Huang YS , Han J , Li C , Yang T . The relationship between postoperative complications and long-term survival after liver resection of hepatocellular carcinoma. European journal of gastroenterology & hepatology 2017 Nov; 29 (11 ):1314-1315. (共同第一)

    4. Huang YZhang LShi YMa SLiao MBai CZhang QWang CLuo FYu SQin SZhi XZhou C. Efficacy of erlotinib in previously treated patients with advanced non-small cell lung cancer: analysis of the Chinese subpopulation in the TRUST study. Jpn J Clin Oncol. 2015 Apr 7. (SCI收錄)

    5. Huang YS, Xue Z, Zhang H. Sorafenib reverses resistance of gastric cancer to treatment by cisplatin through down-regulating MDR1 expression. Med Oncol. 2015 ;32(2):470. (SCI收錄)

    6. Lin HHuang YS(共同第一), Yan HHYang XNZhong WZYe HWYang JJZhou QWu YL. A family history of cancer and lung cancer risk in never-smokers: A clinic-based case-control study. Lung Cancer. 2015 May 27.(SCI收錄)

    7. Huang YS, Yang JJ, Zhang XC, Yang XN, Huang YJ, Xu CR, Zhou Q, Wang Z, Su J, Wu YL*.The Impact of Smoking Status and Pathologic Type on EGFR Mutations in Lung Cancer .Chin Med J (Engl). 2011,124(16):2457-60,(SCI收錄)

    8.Huang YS, Huang B, Wu YL*.Manifestation of leukoencephalopathy in a patient with advanced non-small cell lung cancer following treatment with gefitinib. Chin Med J (Engl). 2011,124(22) :3834-3837(SCI收錄)

    9. An SJ, Huang YS(共同第一), Chen ZH, Han JF, Yang JJ, Zhou Q, Xie Z, Yang Y, Yan HH, Wu YL*. Lower Ras expression as an independent predictor of patient outcomes in lung cancer treated with bevacizumab plus chemotherapy. Cancer Gene Ther. 2014 ;21(3):110-4. (SCI收錄)

    10.Chao L, Yi-Sheng H(共同第一), Yu C, Li-Xu Y, Xin-Lan L, Dong-Lan L, Jie C, Yi-Lon W, Hui LY.Relevance of EGFR mutation with micropapillary pattern according to the novel IASLC/ATS/ERS lung adenocarcinoma classification and correlation with prognosis in Chinese patients. Lung cancer.2014; 86( 2): 164–169(SCI收錄)

    11. Huang YS, An SJ, Chen ZH, Wu YL*.Three cases of severe hepatic impairment caused by erlotinib. Br J Clin Pharmacol. 2009,68(3):464-7.(SCI收錄)

    12. Wu YL*, Zhou C, Cheng Y, Lu S, Chen GY, Huang C, Huang YS, Yan HH, Ren S, Liu Y, Yang JJ. Erlotinib as second-line treatment in patients with advanced non-small-cell lung cancer and asymptomatic brain metastases: a phase II study (CTONG-0803).Ann Oncol. 2013 ,24(4):993-9.(SCI收錄)

    13.  Yang JJ, Zhou C, Huang Y, Feng J, Lu S, Song Y, Huang C, Wu G, Zhang L, Cheng Y, Hu C, Chen G, Zhang L, Liu X, Yan HH, Tan FL, Zhong W, Wu YL. Icotinib versus whole-brain irradiation in patients with EGFR-mutant non-small-cell lung cancer and multiple brain metastases (BRAIN): a multicentre, phase 3, open-label, parallel, randomised controlled trial. Lancet Respir Med. 2017 Sep;5(9):707-716.

    14. Yang JJ, Chen HJ, Yan HH, Zhang XC, Zhou Q Su J, Wang Z, Xu CR, Huang YS, Wang BC, Yang XN, Zhong WZ, Nie Q, Liao RQ, Jiang BY, Dong S, Wu YL*. Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer. Lung Cancer. 2013,79(1):33-9. (SCI收錄)

    15. An SJ, Huang YS, Chen ZH, Su J, Yang Y, Chen JG, Yan HH, Lin QX, Yang JJ,  Yang XN, Zhou Q, Zhang XC, Wu YL*.Posttreatment plasma VEGF levels may be associated with the overall survival of patients with advanced non-small cell lung cancer treated with bevacizumab plus chemotherapy. Med Oncol. 2012, 29(2):627-32 (SCI收錄)

    16. Zhou Q, Zhang XC, Chen ZH, Yin XL, Yang JJ, Xu CR, Yan HH, Chen HJ, Su J, Zhong WZ, Yang XN, An SJ, Wang BC, Huang YS, Wang Z, Wu YL*. Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung cancer. J Clin Oncol. 2011,20;29(24):3316-21.(SCI收錄)

    17. Yang JJ, Zhang XC, Su J, Xu CR, Zhou Q, Tian HX, Xie Z, Chen HJ, Huang YS, Jiang BY, Wang Z, Wang BC, Yang XN, Zhong WZ, Nie Q, Liao RQ, Mok TS, Wu YL*.Lung Cancers with Concomitant EGFR Mutations and ALK Rearrangements: Diverse Responses to EGFR-TKI and Crizotinib in Relation to Diverse Receptors Phosphorylation. Clin Cancer Res. 2014;20(5):1383-92.(SCI收錄)

    18. Zeng Z, Yan HH, Zhang XC, Zhong WZ, He YY, Guan JL, Niu FY, Xie Z, Huang YS, Xu CR, Dong S, Wu YL. Reduced chemotherapy sensitivity in EGFR-mutant lung cancer patient with frontline EGFR tyrosine kinase inhibitor. Lung Cancer. 2014 ;86(2):219-24. (SCI收錄)

    醫(yī)生感言:尊重生命,關(guān)愛(ài)患者。



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